A clinical retrospective study was performed on 67 cases, 1 month to 15 years of age,
which were diagnosed as DIC at the Department of Pediatrics, Seoul National University
Children's Hospital from Jan. 1980 to Dec. 1989.
The results were as follows :
1) There were 42 males and 25 females, and 62.7% of total patients were 5 years of
age or younger.
2) Infection was the most common underlying disease as 35 cases (52.2%), followed
by malignancy, liver disease, in order.
3) As of etiologic organisms of sepsis, Gram (-) organisms were more frequent than
Gram (＋) organisms.
4) The most common malignant tumor was leukemia followed by NHL, Burkitt's
lymphoma, neuroblastoma and the most frequent type of leukemia was acute.
promyelocytic leukemia.
5) The hemorrhagic signs were petechiae, gastrointestinal bleeding, hematuria,
pulmonary hemorrhage, ecchymoses, gum bleeding, epistaxis and intracranial hemorrhage.
6) The thrombotic signs thought to be caused by DIC were azotemia and oliguria.
7) The most useful and consistently abnormal findings were increased FDP and
thrombocytopenia.
8) The effective rates on DIC of Gabexate mesilate and conservative treatment only
were 47.8% and 26.1%, respectively. Although there was no statistically significant
difference (p>0.10), Gabexate mesilate-treated group showed higher effective rate.
9) Regardless of the use of Gabexate mesilate, there was little difference between the
mortality rates based on death of bleeding related to DIC (P>0.5), but the number of
cases was too small to reach a definitive conclusion.
|